Cole-Hamilton is a British surname. It can refer to:
Alex Cole-Hamilton (born 1977), Scottish politician Arthur Cole-Hamilton (1750–1810), Anglo-Irish politician Anni Cole-Hamilton, founder of Moray Firth School John Cole-Hamilton (1894–1945), British Royal Air Force commander Richard Cole-Hamilton (1877–1959), English Anglican priest
See also Josh Hamilton (actor) (born 1969), American actor, born Joshua Cole Hamilton