The Orson Ames House is a historic house located at 3339 Main Street in Mexico, New York.

Description and history It was built in about 1830, and is a single-story frame structure with a heavy timber post and beam frame and plank walls. The main block is 36 feet wide and 24 feet deep. A major alteration occurred about 1930 and the kitchen was rebuilt in 1960. In 1851, Orson Ames sheltered at the home the famous fugitive slave William "Jerry" Henry. Note: This includes and Accompanying two photographs

It was listed on the National Register of Historic Places on December 4, 2001.

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