Clarence Smith may refer to:

Sportspeople Clarence Smith (baseball), Negro leagues player, 1921–1933 Clarence Smith (soccer), American soccer player Pop-Boy Smith (Clarence Ossie Smith, 1892–1924), Major League Baseball pitcher Clarence Smith (cricketer) (1902–1982), South African cricketer

Musicians Sonny Rhodes (Clarence Smith, 1940–2021), blues singer and guitarist Pinetop Smith (Clarence Smith, 1904–1929), jazz pianist

Others Clarence Smith (politician) (1849–1941), British Member of Parliament for Kingston upon Hull East, 1892–1895 Clarence Herbert Smith (1865–1901), Australian agriculturalist, engineer, blacksmith and inventor Clarence L. Smith (1894–1951), American architect Clarence O. Smith (1931–2025), American media executive and co-founder of Essence magazine Clarence 13X (Clarence Smith, 1928–1969), founder of the Five Percent Nation Clarence A. Smith, director of the Centers for Disease Control and Prevention

See also William Gervase Clarence-Smith, British economic historian