MLS, or Major League Soccer, is a men's professional soccer league in the United States and Canada.

MLS may also refer to:

Academic degrees Master of Arts in Liberal Studies or Master of Liberal Studies Master of Library and Information Science or Master of Library Science, US and Canada Master of Studies in Law or Master of Legal Studies

Computer technology Maximum length sequence, a type of pseudorandom binary sequence MLS (Making Life Simple) S.A., a Greek software and telecommunications company Messaging Layer Security, a key agreement protocol Mozilla Location Service, a geolocation service Multilayer switch, in computer networking Multilevel security

Other Maritime Launch Services, a Canadian space transport services company Medical laboratory scientist Member of the Leibniz Society of Sciences Michigan Lutheran Seminary Microwave landing system, a radio guidance system Microwave limb sounders, measuring microwave emission from Earth's upper atmosphere Ministry of Strategic Affairs (, HaMisrad LeNos'im Estrategi'im), an Israeli government ministry Multi-layer steel, a type of automotive head gasket Multiple listing service of real estate brokers Myles Lewis-Skelly (born 2006), English footballer "MLS", a Gorillaz song from their 2020 album Song Machine, Season One: Strange Timez "MLS", a nickname for Myles Lewis-Skelly

See also MSL (disambiguation)