Gasperini is an Italian surname. Notable people with the surname include:
Gian Piero Gasperini (born 1958), Italian football player and coach Giovanni Gasperini (1886–?), Italian gymnast Maria Caserini née Gasperini (1884–1969), Italian stage and film actress
See also A commune in Pecetto di Valenza Gasperini v. Center for Humanities (1996), a US Supreme Court case