DeSoto High School can refer to:
DeSoto High School (Texas), DeSoto, Texas De Soto High School (Kansas), De Soto, Kansas De Soto High School (Wisconsin), De Soto, Wisconsin De Soto High School (Missouri), De Soto, Missouri
See also DeSoto Central High School, Southaven, Mississippi DeSoto County High School, Arcadia, Florida North DeSoto High School, Stonewall, Louisiana