The 1920–21 season was divided into two leagues, Liga Mexicana () and Liga Nacional (). After the expulsion of Tigres México from the league, España FC and España Veracruz withdrew in solidarity. España FC changed its name to Real Club España and decided to form their own league called Liga Nacional. Due to the separation of the leagues, the champions were annulled by the amateur organizing body, which was the Asociación de Aficionados de México en la Liga de Football ().
Standings Liga Mexicana The 5 participating clubs from Mexico City, and all the matches were played at Parque Asturias. Pachuca AC and Deportivo Español were dissolved. In replacement Deportivo Internacional and Club Morelos joined the league. ClubPldWDLPtsAsturias FC852112Deportivo Internacional73319Club Morelos72236Germania FV71335Club México71244
Liga Nacional The 5 participating teams from Mexico City, and all the matches were played at Parque España. Reforma AC, Club América, Luz y Fuerza and L'Amicale Française joined the Liga Nacional. ClubPldWDLPtsRC España862014Club América843111L'Amicale Française83147Luz y Fuerza82064Reforma AC81254
References Mexico 1920-21 Mexico - List of final tables (RSSSF)