E41, E-41 or E.41 may refer to: HMS E41, a United Kingdom Royal Navy E-class submarine which saw service during World War I European route E41, a road in Germany and Switzerland DB Class E 41, a locomotive manufactured in Germany Nimzo-Indian Defense, Encyclopaedia of Chess Openings code Tōkai-Hokuriku Expressway and Nōetsu Expressway, route E41 in Japan Long Win Bus Route E41 in Hong Kong