Thomas Mayne may refer to:
Thomas Mayne (politician) (1832–1915), member of parliament (MP) for Mid Tipperary, 1885–1890 Thomas Mayne (inventor) (1901–1995), Australian industrial chemist, inventor of the Nestlé drink Milo Thomas Mayne (rugby union) (1893–1961), Irish international rugby union footballer Thomas Mayne, MP for Newcastle-under-Lyme
See also Thom Mayne (born 1944), American architect Thomas Mayne Reid (1818–1883), Irish-American novelist