William Middleton may refer to:
Politicians William Middleton (by 1533 – 1574 or later), MP for Carlisle Sir William Middleton, 3rd Baronet, British member of parliament for Northumberland, 1722–1757 Sir William Middleton, 5th Baronet, British member of parliament for Northumberland, 1774–1795 Sir William Fowle Middleton, 1st Baronet (1748–1829), British member of parliament for Ipswich, and for Hastings
Others William Middleton (bishop) (died 1288), medieval bishop of Norwich Wiliam Midleton (c. 1550–1596), Welsh poet and adventurer William Middleton (pamphleteer) (died 1613), English churchman, academic and Protestant controversialist Bay Middleton (William George Middleton, 1846–1892), equerry to John Spencer, 5th Earl Spencer William Shainline Middleton (1890–1975), American internist William James Middleton (1897–1918), World War I flying ace William D. Middleton (1928–2011), author, reporter and photographer William Middleton (American football) (born 1986), American football cornerback William Middleton (writer), journalist and writer Billy Middleton (1893–?), English football forward Bill Middleton (1920–1951), Australian rugby league player