Boffo may refer to:
People Francesco Boffo (1796–1867), Swiss architect responsible for many buildings in southern Russia and Ukraine Dino Boffo (born 1952), Italian journalist Adolfo Bautista (born 1979), Mexican midfielder nicknamed "Bofo"
Fiction Mister Boffo, a comic strip created by Joe Martin Phineas Boffo, a character in the TV series Carnivàle Boffo, a psychological trick employed by the witch Eumenides Treason in Terry Pratchett's Discworld series
Other BOFFO, a nonprofit arts organization in Fire Island Pines, New York Boffo Games, a video game developer