Brizio is a surname. Notable people with the surname include:
Anna Maria Brizio (1902–1982), Italian professor of art history Arturo Brizio Carter (born 1956), Mexican football referee Edoardo Brizio (1846–1907), Italian archaeologist Emanuela Brizio (born 1969), Italian mountain runner Francesco Brizio (1574–1623), Italian painter and engraver
See also Brizio Giustiniani (1713–1778), 174th Doge of the Republic of Genoa