The 1999 William & Mary Tribe football team represented the College of William & Mary as member of the Atlantic 10 Conference (A-10) during the 1999 NCAA Division I-AA football season. Led by Jimmye Laycock in his 20th year as head coach, William & Mary finished the season with an overall record of 6–5 and a mark of 5–3 in A-10 play, tying for fourth place.

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