Coumaroyl-coenzyme A is the thioester of coenzyme-A and coumaric acid. Coumaroyl-coenzyme A is a central intermediate in the biosynthesis of myriad natural products found in plants. These products include lignols (precursors to lignin and lignocellulose), flavonoids, isoflavonoids, coumarins, aurones, stilbenes, catechin, and other phenylpropanoids.
Biosynthesis and significance It is generated in nature from phenylalanine, which is converted by PAL to trans-cinnamate. Trans-cinnamate is hydroxylated by trans-cinnamate 4-monooxygenase to give 4-hydroxycinnamate (i.e, coumarate). Coumarate is condensed with coenzyme-A in the presence of 4-coumarate-CoA ligase: ATP + 4-coumarate + CoA AMP + diphosphate + 4-coumaroyl-CoA.
Enzymes using Coumaroyl-Coenzyme A Anthocyanin 3-O-glucoside 6''-O-hydroxycinnamoyltransferase Anthocyanin 5-aromatic acyltransferase Chalcone synthase 4-Coumarate-CoA ligase 6'-Deoxychalcone synthase Agmatine N4-coumaroyltransferase Flavonol-3-O-triglucoside O-coumaroyltransferase Naringenin-chalcone synthase Shikimate O-hydroxycinnamoyltransferase Trihydroxystilbene synthase
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