Charles Duffy may refer to:
Charles Cashel Gavan Duffy (1855–1932), Australian public servant Charles Gavan Duffy (1816–1903), Irish nationalist, journalist, poet and Australian politician Charles Gavan Duffy (Canadian politician) (1874–1958), Canadian politician Charles John Duffy (1919–1941), U.S. Navy officer Charles Lee Duffy (born 1976), American serial killer Charles Leonard Gavan Duffy (1882–1961), Australian judge