Sayler is a surname. Notable people with the surname include:
Henry B. Sayler (1836–1900), American politician, cousin of Milton Jace Sayler (born 1979), American football player Milton Sayler (1831–1892), American politician
See also Battle of Sayler's Creek, fought April 6, 1865, southwest of Petersburg, Virginia Sayler Park, Cincinnati, neighborhood in Cincinnati, Ohio Sayler's Creek Battlefield near Farmville, Virginia