Synthetoceratinae is an extinct subfamily of Protoceratidae, deer-like herbivorous mammals belonging to the order Artiodactyla. They were endemic to North America during the Miocene epoch, living 23.03—3.9 Ma, existing for approximately .

Taxonomy Synthetoceratinae was named by Frick (1937). Its type genus is Synthetoceras. It was considered monophyletic by Webb et al. (2003). It was assigned to Protoceratidae by Webb (1981), Prothero (1998),D. R. Prothero. 1998. Protoceratidae. In C. M. Janis, K. M. Scott, and L. L. Jacobs (eds.), Evolution of Tertiary mammals of North America 431-438 Webb et al. (2003),S. D. Webb, B. L. Beatty, and G. Poinar, Jr. 2003. New evidence of Miocene Protoceratidae including a new species from Chiapas, Mexico. Bulletin of the American Museum of Natural History 279:348-367 Hulbert and Whitmore (2006)R. C. Hulbert and F. C. Whitmore. 2006. Late Miocene mammals from the Mauvilla Local Fauna, Alabama. Bulletin of the Florida Museum of Natural History 46(1):1-28 and Prothero and Ludtke (2007).D. R. Prothero and J. A. Ludtke. 2007. Family Protoceratidae. in D. R. Prothero and S. Foss (eds.), The Evolution of Artiodactyls 169-176

Tribes Synthetoceratinae contains the tribes Kyptoceratini and Synthetoceratini. Tribe Kyptoceratini Genus Kyptoceras Genus Syndyoceras Tribe Synthetoceratini Genus Lambdoceras Genus Prosynthetoceras Genus Synthetoceras

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