Acantholepis is the scientific name of several genera of organisms. It may refer to:

Echinops, a genus of plants; synonym Acantholepis (Less.) Argentina, a genus of fish; synonym Acantholepis (Krøyer, 1846) Lepisiota, a genus of ants; synonym Acantholepis (Mayr, 1861) Eczematolepis, an extinct genus of ptyctodontidan