Purificación may refer to:
Places Purificación, Tolima, a town and municipality in the Tolima department of Colombia Purificación River (Jalisco), a river in Jalisco, Mexico Purificación River (Tamaulipas), a river in Tamaulipas, Mexico Villa Purificación, a town and municipality in Jalisco, Mexico Camp Purificación, headquarters of the Federal League (1815–1820) on the eastern bank of the Uruguay River
People Purificación Ortiz (born 1972), Spanish paralympic athlete Purificación "Purita" Campos (1937–2019), Spanish illustrator Purificación Carpinteyro Calderón (born 1961), Mexican politician and lawyer Purificación Angue Ondo, diplomat from Equatorial Guinea Purificacion Santamarta, Spanish paralympic athlete Purificación Zelaya (1866–1940), Honduran military officer, landlord and politician
See also Purification (disambiguation)