The 1945 William & Mary Indians football team represented the College of William & Mary as a member of the Southern Conference (SoCon) during the 1945 college football season. Led by second-year head coach Rube McCray, the Indians compiled an overall record of 6–3 with a mark of 4–2 in conference play, and finished third in the SoCon. William & Mary played home games at Cary Field in Williamsburg, Virginia.

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NFL draft selections = Pro Football Hall of Fame= Canadian Football Hall of Fame = College Football Hall of Fame NFL Draft Selections  # Year Round Pick Overall Name Team Position10194610888Philadelphia EaglesEnd11194611393Pittsburgh SteelersGuard121946168148Philadelphia EaglesBack131946208188Philadelphia EaglesBack

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