DeSimone or De Simone is an Italian surname. Notable people with the surname include:
DeSimone family A group of related Italian American mobsters: Frank DeSimone, lawyer turned mobster Rosario DeSimone, early Los Angeles mobster Thomas DeSimone
Other people: DeSimone Bob DeSimone (born 1946), American actor Herbert F. DeSimone (1929–2013), American lawyer and politician from Rhode Island James DeSimone (G.I. Joe) Joée, born Joey DeSimone Joseph DeSimone (inventor) Louis A. DeSimone (1922–2018), American Roman Catholic bishop Nick DeSimone (born 1994), American ice hockey player Paul DeSimone, American bodybuilder Robert Desimone, American neuroscientist Tom DeSimone (born 1939), American film director Vincent DeSimone (1918–1979), New Jersey detective
De Simone Carlo De Simone (1885–1951), Italian army officer in World War II Carlo De Simone (linguist) (1932–2023), Italian linguist Domenico de Simone (1768–1837), Italian cardinal Domenico De Simone (1926–2019), Italian politician Fabrizio De Simone (born 1971), Italian racing driver Giorgio De Simone (1932–2024), Italian journalist and writer Giovanni Alfredo De Simone (1919–1985, known as Johnny Desmond), American singer Gustavo de Simone (born 1948), Uruguayan footballer Lenika de Simone (born 1985), Spanish gymnast Niccolò De Simone (died c. 1677), Flemish painter Roberto De Simone (1933–2025), Italian stage director, playwright, composer and ethnomusicologist Titti De Simone (born 1970), Italian politician