The year 1595 in science and technology involved some significant events, some of which are listed here.

Chemistry Andreas Libavius publishes Opera omnia medico-chymica.

Exploration July 21 – A Spanish expedition led by Álvaro de Mendaña de Neira makes the first European landing in Polynesia, on the Marquesas Islands. Sir Walter Raleigh explores Guyana and eastern Venezuela.His book The Discovery of Guiana (1596) makes exaggerated claims for his discoveries.

Mathematics Bartholomaeus Pitiscus publishes Trigonometria: sive de solutione triangulorum tractatus brevis et perspicuus in Heidelberg, introducing the term trigonometry to Western European languages.Groundbreaking Scientific Experiments, Inventions, and Discoveries.

Medicine 1595–1596 – Scipione (Girolamo) Mercurio publishes ("The midwife"), the first text to advocate a Caesarean section on the living in cases of a contracted long pelvis. A first chair of medicine is created at Uppsala in Sweden. It will remain vacant until the appointment, in 1613, of .

Technology Hull of first fluyt laid in the Dutch Republic.

Births June 13 – Jan Marek Marci, Bohemian physician (died 1667). Cornelius Vermuyden, Dutch drainage engineer (died 1677).

Deaths August 24 – Thomas Digges, English astronomer (born 1546). November 12 – Sir John Hawkins, English navigator (born 1532) (at sea).

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