Harpalus or Harpalos (Ancient Greek: ) may refer to:

Greek Antiquity Harpalus courtier of Alexander the Great and embezzler of the Persian treasure. Harpalus (astronomer) astronomer of 5th-century BC Harpalus (engineer) supposed engineer of Xerxes in the Hellespont Harpalus (son of Polemaeus) statesman of Perseus of Macedon Harpalus (mythology) mythological character of Laconia Harpalos, one of the dogs that tore apart Actaeon

Science Harpalus (beetle) of carabid beetles Harpalus (crater) on the Moon