Prisco is both a given name and surname. Notable people with the name include:

As a given or middle name

Prisco Nilo (born 1957), Filipino meteorologist

Pietro Prisco Guglielmucci (died 1539), Italian Roman Catholic Bishop of Lavello (1515–1539)

As a surname Giuseppe Antonio Ermenegildo Prisco (1833-1923), Italian Roman Catholic Church Cardinal and Archbishop of Naples Albert Prisco (1890–?), American actor Angelo Prisco (born 1939), American mobster Giulio Prisco (born 1957), Italian physicist Giuseppe Antonio Ermenegildo Prisco (1833–1923), Italian cardinal Lorenzo Prisco (born 1987), Italian footballer Michele Prisco (1920–2003), Italian journalist Nick Prisco (1909–1981), American football player

As a nickname Teodoro "Prisco" Alcalde Millos (1913–1995), Peruvian footballer

See also Prisco (disambiguation)