This is a list of annual sales of patented medications per pharmaceutical group. Because it derives from 10-K data, drugs that have passed loss of exclusivity (LOE) will cease to be on this list.
Annual Sales (2020-present)
MedicationTrade namePrimary IndicationCompany20242023202220212020atorvastatinLipitorReduction of LDL cholesterolPfizersunitinib malateSutentAdvanced and/or metastatic renal cell carcinoma (mRCC) & refractory gastrointestinal stromal tumors (GIST)PfizeririnotecanCamptosarMetastatic colorectal cancerPfizerbimatoprostLumiganOpen-angle glaucoma or ocular hypertensionAllerganexemestaneAromasinBreast cancerPfizerepirubicinEllenceBreast cancerPfizertrastuzumabHerceptinHER2-positive metastatic breast cancerGenentechgemcitabineGemzarOvarian cancer, non-small cell lung cancer (NSCLC), metastatic breast cancer (MBC), and pancreatic cancerEli Lilly & Co.bevacizumabAvastinMetastatic colorectal cancer, non-small cell lung cancer (NSCLC), renal cell carcinoma, HER2-negative breast cancerGenentecherlotinibTarcevaAdvanced (metastatic) non-small cell lung cancer (NSCLC)GenentechbrimonidineAlphaganOpen-angle glaucoma or ocular hypertensionAllerganrituximabRituxanNon-Hodgkin's lymphoma and rheumatoid arthritisGenentechranibizumabLucentisAge-related macular degeneration (AMD)GenentechomalizumabXolairAsthmaGenentechsomatropinNutropinGrowth hormone deficiency, chronic kidney diseaseGenentechdornase alfaPulmozymeCystic fibrosis (CF)GenentechefalizumabRaptivaPlaque psoriasisGenentechmontelukastSingulairAsthmaMerckalendronate sodiumFosamaxPostmenopausal osteoporosisMercksitagliptinJanuviaType 2 diabetesMercksimvastatinZocorReduction of LDL cholesterolMerckrizatriptan benzoateMaxaltMigraine painMerckfinasteridePropeciaHair lossMercketoricoxibArcoxiaOsteoarthritis and rheumatoid arthritisMercksitagliptin/metformin HClJanumetType 2 diabetesMerckfinasterideProscarBenign prostatic hyperplasia (enlarged prostate)MerckaprepitantEmendNausea and vomiting prevention caused by chemotherapyMerckolanzapineZyprexaSchizophreniaEli Lilly & Co.duloxetine HClCymbaltaDepression and generalized anxiety disorderEli Lilly & Co.insulin lisproHumalogType 1 diabetes in adultsEli Lilly & Co.pemetrexedAlimtaLocally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC)Eli Lilly & Co.raloxifene HClEvistaOsteoporosisEli Lilly & Co.insulin isophaneHumulinDiabetesEli Lilly & Co.teriparatideForteoOsteoporosisEli Lilly & Co.atomoxetine HClStratteraAttention-deficit/hyperactivity disorder (ADHD)Eli Lilly & Co.timolol IstalolOpen-angle glaucomaIsta Pharmaceuticalbromfenac XibromOcular inflammationIsta Pharmaceuticalhyaluronidase VitraseSpreading agentIsta PharmaceuticarivaroxabanXareltoDeep vein thrombosisJohnson & Johnson
Annual Sales (2010-2020)
MedicationTrade namePrimary IndicationCompanyatorvastatinLipitorReduction of LDL cholesterolPfizer20202019201820172016201520142013201220112010sunitinib malateSutentAdvanced and/or metastatic renal cell carcinoma (mRCC) & refractory gastrointestinal stromal tumors (GIST)PfizeririnotecanCamptosarMetastatic colorectal cancerPfizerbimatoprostLumiganOpen-angle glaucoma or ocular hypertensionAllerganexemestaneAromasinBreast cancerPfizerepirubicinEllenceBreast cancerPfizertrastuzumabHerceptinHER2-positive metastatic breast cancerGenentechgemcitabineGemzarOvarian cancer, non-small cell lung cancer (NSCLC), metastatic breast cancer (MBC), and pancreatic cancerEli Lilly & Co.bevacizumabAvastinMetastatic colorectal cancer, non-small cell lung cancer (NSCLC), renal cell carcinoma, HER2-negative breast cancerGenentecherlotinibTarcevaAdvanced (metastatic) non-small cell lung cancer (NSCLC)GenentechbrimonidineAlphaganOpen-angle glaucoma or ocular hypertensionAllerganrituximabRituxanNon-Hodgkin's lymphoma and rheumatoid arthritisGenentechranibizumabLucentisAge-related macular degeneration (AMD)GenentechomalizumabXolairAsthmaGenentechsomatropinNutropinGrowth hormone deficiency, chronic kidney diseaseGenentechdornase alfaPulmozymeCystic fibrosis (CF)GenentechefalizumabRaptivaPlaque psoriasisGenentechmontelukastSingulairAsthmaMerckalendronate sodiumFosamaxPostmenopausal osteoporosisMercksitagliptinJanuviaType 2 diabetesMercksimvastatinZocorReduction of LDL cholesterolMerckrizatriptan benzoateMaxaltMigraine painMerckfinasteridePropeciaHair lossMercketoricoxibArcoxiaOsteoarthritis and rheumatoid arthritisMercksitagliptin/metformin HClJanumetType 2 diabetesMerckfinasterideProscarBenign prostatic hyperplasia (enlarged prostate)MerckaprepitantEmendNausea and vomiting prevention caused by chemotherapyMerckolanzapineZyprexaSchizophreniaEli Lilly & Co.duloxetine HClCymbaltaDepression and generalized anxiety disorderEli Lilly & Co.insulin lisproHumalogType 1 diabetes in adultsEli Lilly & Co.pemetrexedAlimtaLocally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC)Eli Lilly & Co.raloxifene HClEvistaOsteoporosisEli Lilly & Co.insulin isophaneHumulinDiabetesEli Lilly & Co.teriparatideForteoOsteoporosisEli Lilly & Co.atomoxetine HClStratteraAttention-deficit/hyperactivity disorder (ADHD)Eli Lilly & Co.timolol IstalolOpen-angle glaucomaIsta Pharmaceuticalbromfenac XibromOcular inflammationIsta Pharmaceuticalhyaluronidase VitraseSpreading agentIsta PharmaceuticarivaroxabanXareltoDeep vein thrombosisJohnson & Johnson
Annual Sales (2000-2010)
MedicationTrade namePrimary IndicationCompany201020092008, Genentech 2008 10-K., Pfizer 2008 10-K., Eli Lilly & Co. 2008 10-K., Allergan 2008 10-K., Merck 2008 10-K., Ista Pharmaceuticals 2008 10-K.2007, Genentech 2007 10-K., Pfizer 2007 10-K., Eli Lilly & Co. 2007 10-K., Allergan 2007 10-K., Merck 2007 10-K., Ista Pharmaceuticals 2007 10-K.2006, Genentech 2006 10-K., Pfizer 2006 10-K., Eli Lilly & Co. 2006 10-K., Allergan 2006 10-K., Merck 2006 10-K., Ista Pharmaceuticals 2006 10-K.2005, Genentech 2005 10-K., Pfizer 2005 10-K., Eli Lilly & Co. 2005 10-K., Allergan 2005 10-K., Merck 2005 10-K.2004, Genentech 2004 10-K., Pfizer 2004 10-K., Eli Lilly & Co. 2004 10-K., Allergan 2004 10-K.2003, Genentech 2003 10-K., Pfizer 2003 10-K., Eli Lilly & Co. 2003 10-K., Allergan 2003 10-K.2002, Genentech 2002 10-K., Pfizer 2002 10-K., Eli Lilly & Co. 2002 10-K., Allergan 2002 10-K.2001, Pfizer 2001 10-K.2000, Genentech 2000 10-K., Eli Lilly & Co. 2000 10-K.atorvastatinLipitorReduction of LDL cholesterolPfizer$12,401$12,675$12,886$12,187$10,862$9,231$7,972$6,448$5,028sunitinib malateSutentAdvanced and/or metastatic renal cell carcinoma (mRCC) & refractory gastrointestinal stromal tumors (GIST)Pfizer$847$581$219irinotecanCamptosarMetastatic colorectal cancerPfizer$563$969$903$910$554$299bimatoprostLumiganOpen-angle glaucoma or ocular hypertensionAllergan$426.2$391.7$327.5$267.6$232.9$181.3$123$35.4exemestaneAromasinBreast cancerPfizer$465$401$320$247$143$58epirubicinEllenceBreast cancerPfizer$312$367$344$216trastuzumabHerceptinHER2-positive metastatic breast cancerGenentech$1,382$1,287$1,234$747.2$483.2$424.8$385.2$346.7$276gemcitabineGemzarOvarian cancer, non-small cell lung cancer (NSCLC), metastatic breast cancer (MBC), and pancreatic cancerEli Lilly & Co.$1,719.8$1,592.4$1,408.1$1,334.5$1,214.4$1,021.7$875$723$559.3bevacizumabAvastinMetastatic colorectal cancer, non-small cell lung cancer (NSCLC), renal cell carcinoma, HER2-negative breast cancerGenentech$2,686$2,296$1,746$1,132$554.6erlotinibTarcevaAdvanced (metastatic) non-small cell lung cancer (NSCLC)Genentech$457$417$402$274.9$13.3brimonidineAlphaganOpen-angle glaucoma or ocular hypertensionAllergan$286.8$248.5$250.9rituximabRituxanNon-Hodgkin's lymphoma and rheumatoid arthritisGenentech$2,587$2,285$2,071$1,831.4$1,574$1,360.2$1,162.9$818.6ranibizumabLucentisAge-related macular degeneration (AMD)Genentech$875$815$380omalizumabXolairAsthmaGenentech$517$472$425$320.6$187.6$25.1somatropinNutropinGrowth hormone deficiency, chronic kidney diseaseGenentech$358$371$378$370.5$348.8$319.5dornase alfaPulmozymeCystic fibrosis (CF)Genentech$257$223$199$186.5$157.1$143.7$138.1$123efalizumabRaptivaPlaque psoriasisGenentech$108$107$90$79.2$52.4$1.4montelukastSingulairAsthmaMerck$4,336.9$4,266.3$3,579$2,975.6$2,622alendronate sodiumFosamaxPostmenopausal osteoporosisMerck$1,552.7$3,049$3,134.4$3,191.2$3,159.7sitagliptinJanuviaType 2 diabetesMerck$1,397.1$667.5$42.9simvastatinZocorReduction of LDL cholesterolMerck$660.1$876.5$2,802.7$4,381.7$5,196.5rizatriptan benzoateMaxaltMigraine painMerck$529.2$467.3$406.4$348.4$309.9finasteridePropeciaHair lossMerck$429.1$405.4$351.8$291.9$270.2etoricoxibArcoxiaOsteoarthritis and rheumatoid arthritisMerck$377.3$329.1$265.4$218.2sitagliptin/metformin HClJanumetType 2 diabetesMerck$351.1$86.4finasterideProscarBenign prostatic hyperplasia (enlarged prostate)Merck$323.5$411$618.5$741.4$733.1aprepitantEmendNausea and vomiting prevention caused by chemotherapyMerck$263.8$204.2$130.8$87olanzapineZyprexaSchizophreniaEli Lilly & Co.$4,696.1$4,761$4,363.6$4,202.3$4,419.8$4,276.9$3,689$3,087$2,349.5duloxetine HClCymbaltaDepression and generalized anxiety disorderEli Lilly & Co.$2,697.1$2,102.9$1,316.4$679.7$93.9insulin lisproHumalogType 1 diabetes in adultsEli Lilly & Co.$1,735.8$1,474.6$1,299.5$1,197.7$1,101.6$1,021.3$834$628$350.2pemetrexedAlimtaLocally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC)Eli Lilly & Co.$1,154.7$854$611.8$463.2$142.6raloxifene HClEvistaOsteoporosisEli Lilly & Co.$1,075.6$1,090.7$1,045.3$1,036.1$1,012.7$922.1$822$665$521.5insulin isophaneHumulinDiabetesEli Lilly & Co.$1,063.2$985.2$925.3$1,004.7$997.7$1,060.4$1,004$1,061$1,114.5teriparatideForteoOsteoporosisEli Lilly & Co.$778.7$709.3$594.3$389.3$238.6$65.3atomoxetine HClStratteraAttention-deficit/hyperactivity disorder (ADHD)Eli Lilly & Co.$579.5$569.4$579$552.1$666.7$370.3timolol IstalolOpen-angle glaucomaIsta Pharmaceutical$14.6$11.3$8.3$2.6bromfenac XibromOcular inflammationIsta Pharmaceutical$63$42.1$20.2$5.3hyaluronidase VitraseSpreading agentIsta Pharmaceutica$5.2$5.2$4.2$2.5rivaroxabanXareltoDeep vein thrombosisJohnson & Johnson$1,868$1,522$864$239$25
Notes