Mesika is a Jewish-Tunisian surname and may refer to:
Erez Mesika, current Israeli midfielder with Hapoel Be'er Sheva Gal Mesika, Israeli American footballer Gershon Mesika, Israeli lawyer and politician Miri Mesika, Israeli singer Reef Mesika, Israeli footballer currently playing for Hapoel Umm al-Fahm Yigal Mesika, Israeli magician known internationally