MTB may refer to:

Science and medicine Magnetotactic bacteria Mediterranean tamarisk beetle Multilobular tumour of bone, canine disease Mycobacterium tuberculosis

Transport and vehicles Matlock Bath railway station, England; National Rail station code MTB Mississauga Truck and Bus Collision, a Canadian bus manufacturer Motor torpedo boat Mountain bike

Other uses M&T Bank of New York, NYSE symbol Magandang Tanghali Bayan, a variety show in the Philippines The Marshall Tucker Band, a band from Spartanburg, South Carolina, United States Minus the Bear, a band from Seattle, Washington, United States Mutual Trust Bank, a bank in Bangladesh My Therapy Buddy, a talking plush doll for adults