Lemont Burwell KierLemont B. Kier: art, science and green cheese. G. Restrepo, Curr. Comput-Aid Drug. 12, 314-324 (2016) (September 13, 1930 - Jan 2, 2024) was an American chemist and researcher in the field of drug design and medicinal chemistry.See, for instance Richmond Times and Dispatch, Feb. 26, 2004 "Three Named Top Virginia Scientists" He was the recipient of the American Association of Pharmaceutical Scientists 2008 Research Achievement Award in Drug Development and Discovery. Kier obtained his PhD in Medicinal Chemistry at the University of Minnesota in 1958. His last position was Professor Emeritus of Medicinal Chemistry and Nurse Anesthesia at Virginia Commonwealth University in Richmond, Virginia. He participated in the founding of the Center for the Study of Biological Complexity at Virginia Commonwealth University.L. B. Kier, My Journey Through Structure: The Structure of My Journey, Internet Electron. J. Mol. Des. 2006, 5, 181–191,
Work Kier built one of the first models in which molecular orbital theory was applied successfully to drug design and development. Later, he and his colleague, Lowell Hall, developed what is now called the "Kier-Hall Index" to describe molecular connectivity."From chemical topology to three-dimensional geometry" by Alexandru T. Balaban, Springer Books, 1997, p. 7Molecular drug properties: measurement and prediction - Google Books Result by Raimund Mannhold, Wilel VVH (2007) pp. 88-90 His particular expertise in the question “How do chemical modifications affect particular physical properties of drugs?” has been used to develop the theory of the interaction of general anesthetic gases with the body,Molecular Connectivity and SAR of General Anesthetics. T. Dipaolo, L. B. Kier and L. H. Hall, Molec. Pharmacol., 13, 31 (1977) and the theory of taste (and in particular, sweetness).
Professor Kier is the author or co-author of eight books:Lemont B. Kier: a bibliometric exploration of his scientific production and its use. G. Restrepo, E. J. Llanos and A. E. Silva, Curr. Comput-Aid Drug. 9, 491-505 (2013) Molecular Orbital Theory In Drug Research;Molecular Orbital Theory In Drug Research. L. B. Kier, Academic Press, New York (1971) Molecular Connectivity In Chemistry and Drug Research;Molecular Connectivity In Chemistry and Drug Research L. B. Kier and L. H. Hall, Academic Press, New York (1976) Molecular Connectivity in Structure Activity Analysis;Molecular Connectivity in Structure Activity Analysis. L. B. Kier and L. H. Hall, John Wiley Publ, London (1986) Molecular Structure Description: The Electrotopological State;Molecular Structure Description: The Electrotopological State L. B. Kier and L. H. Hall, Academic Press, San Diego, (1999) Medicinal Chemistry and Physics for Nurse Anesthetists;Medicinal Chemistry and Physics for Nurse Anesthetists L. B. Kier and C. Dowd Amer. Assoc. of Nurse Anesthetists, Chicago (2004) Cellular Automata Modeling of Chemical Systems;Cellular Automata Modeling of Chemical Systems. L. B. Kier, P. G. Seybold and C.-K. Cheng, Springer, Amsterdam (2005) and Science and Complexity for Life Science Students.Science and Complexity for Life Science Students. L. B. Kier, Kendall/Hunt, Dubuque, IO, (2007)
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External links
VCU faculty page Google Scholar page