Santillán or Santillan is a Spanish surname. Notable people with the surname include:
Akira Santillan (born 1997), Australian tennis player Diego Abad de Santillán (1897–1983), Spanish Argentine author, economist, leading figure in the Spanish and Argentine anarchist movements Jesica Santillan (1985–2003), undocumented immigrant from Mexico who died after an organ transplant operation in the U.S. Julian Hernández Santillán (born 1963), Mexican politician Manuel Santillán (1894–1982), Mexican geological engineer and politician Mario Santillán (born 1981), Mexican Paralympian athlete Maxie Santillan Jr. (1956–2022), American actor Pedro Velarde y Santillán (1779–1808), Spanish artillery captain famous for his heroic death Pura Santillan-Castrence (1905–2007), Filipino writer and diplomat Ramón de Santillán, (1791–1863), Spanish soldier, politician, and minister of finance Tony Santillan (born 1997), American baseball player
See also Huétor Santillán, municipality located in the province of Granada, Spain Tasa de Santillán or Rate of Santillán, a rate of indigenous labor applied in the Kingdom of Chile Santillana (disambiguation)