The acronym LPSS may refer to:

A US Navy hull classification symbol: Transport submarine (LPSS) Lorne Park Secondary School, a high school in Mississauga, Ontario, Canada Lambrick Park Secondary School, a high school in Saanich, British Columbia, Canada Lafayette Parish School System, a school district in Louisiana Lucent Public Safety Systems, a company acquired by Intrado Labour Party South Sudan Low Power Subsystems, a management class of subsystems in the Linux kernel