Mbeki is a surname of South African and Xhosa origin. Notable people with the surname include:

Mbeki family Govan Mbeki, the father of Thabo Mbeki, politician, military commander, Communist leader Skelewu Mbeki, chief of the Mpukane village in the Nqamakwe district and the father of Govan Mbeki. Epainette Mbeki, the mother of Thabo Mbeki, known as "MaMbeki", a stalwart community activist and promoter of women's development Linda Mbeki, first born and only daughter of Govan and only sister of Thabo, and South African political activist Thabo Mbeki, former President of South Africa Zanele Mbeki (née Dlamini), wife of Thabo Mbeki, a feminist South African social worker who founded the Women's Development Bank Monwabisi Kwanda Mbeki, son of Thabo Mbeki Moeletsi Mbeki, son of Govan and brother of Thabo, deputy chairman of the South African Institute of International Affairs Jama Mbeki, last born of Govan and youngest brother of Thabo, and law student