Serio may refer to: Sério, a municipality in Rio Grande do Sul, Brazil Serio (river), a river in Lombardy, Italy Cascate del Serio 11022 Serio, a main belt asteroid
People with the surname José Sério (1922–2010), Portuguese footballer Renato Serio (born 1946), Italian composer, conductor and arranger Steve Serio (born 1987), American wheelchair basketball player
Fictional Serio (HMX-13), a character from the visual novel To Heart