James O'Toole may refer to:
James O'Toole (business figure), pioneer of the internet and internet marketing in Australia, James O'Toole (American politician) (born 1958), politician in the Missouri House of Representatives James O'Toole (reporter), American journalist James O'Toole (mobster) (1929–1973), Irish-American criminal James O'Toole (Irish politician) (died 1969), Irish Fianna Fáil politician
See also Jim O'Toole (1937–2015), American baseball player