X-linked hypertrichosis, also known as X-linked congenital generalized hypertrichosis, is a hereditary disorder characterized by generalized congenital hypertrichosis and thick eyebrows.
Signs and symptoms Hypertrichosis is characterized as excessive hair growth anywhere on the body, in either men or women. X-linked hypertrichosis affects males more than females.
Causes X-linked hypertrichosis was found in a Mexican family to be caused by a 389 kb interchromosomal insertion at an extragenic palindrome site at Xq27.1. The inserted DNA significantly reduces the expression of fibroblast growth factor 13.
X-linked hypertrichosis is inherited in an X-linked dominant pattern of inheritance.
See also Generalized hyperhidrosis List of cutaneous conditions
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