Mezilesí is a municipality and village in Pelhřimov District in the Vysočina Region of the Czech Republic. It has about 100 inhabitants.
Mezilesí lies approximately north-west of Pelhřimov, west of Jihlava, and south-east of Prague.
Administrative division Mezilesí consists of three municipal parts (in brackets population according to the 2021 census): Mezilesí (47) Holýšov (25) Zelená Ves (42)
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