Hora Svatého Šebestiána () is a municipality and village in Chomutov District in the Ústí nad Labem Region of the Czech Republic. It has about 300 inhabitants.

Hora Svatého Šebestiána lies approximately north-west of Chomutov, west of Ústí nad Labem, and north-west of Prague.

Administrative division Hora Svatého Šebestiána consists of two municipal parts (in brackets population according to the 2021 census): Hora Svatého Šebestiána (196) Nová Ves (113)

History The first written mention of Hora Svatého Šebestiána is from 1558.

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