Ononin is an isoflavone glycoside, the 7-O-β-D-glucopyranoside of formononetin, which in turn is the 4'-O-methyl (4'-methoxy) derivative of the parent isoflavone daidzein.
Natural sources Ononin is a major isoflavone found in a number of plants and herbs like soybean, Astragalus root, and Glycyrrhiza uralensis.
Pharmacokinetics Intestinal bacterial metabolic pathways may include demethylation and deglycosylation. It follows that formation of formononetin and/or daidzein is possible.
Pharmacodynamics An in vitro anti-inflammatory effect on lipopolysaccharide (LPS)-induced inflammation has been demonstrated in one study.
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