VRU is an abbreviation of:

Vapor recovery unit, a means for recycling evaporated fuel. Vancouver Rugby Union in Canada. Victorian Rugby Union in Australia. Verkhovna Rada Ukrainy (), Ukraine's unicameral parliament. Vertical reference unit, used for dynamic positioning. Violence Reduction Unit, a division of the Scottish police force. Voice response unit, a telephony system also known as interactive voice response. Vulnerable road user, a concept in road traffic safety. Voice Recognition Unit, an accessory for the Nintendo 64