Sesto may refer to:

People

Surname Camilo Sesto (1946–2019), Spanish singer Cesare da Sesto, (1477–1523) Italian painter Count Sesto, an Italian noble title

Given name Sesto Bruscantini (1919–2003), Italian opera singer Sesto Pals (–2008), Romanian writer Sesto Prete (1919–1991), Italian-American philologist Sesto Rocchi (1909–1991), Italian luthier

Places Sesto al Reghena, Pordenone, Italy Sesto Calende, Varese, Italy Sesto Campano, Isernia, Italy Sesto ed Uniti, Cremona, Italy Sesto Fiorentino, Florence, Italy Sesto San Giovanni, Milano, Italy Sexten (Italian: Sesto), Bolzano, Italy

See also Sestos, an ancient city in Turkey Sestu, an Italian municipality in the Province of Cagliari