The Chocón Machacas River is a river in eastern Guatemala. The sources of the riverCastillo Lemus: 12 are on the eastern slopes of the Sierra de Santa Cruz at . From there it flows in a generally west-south-west direction into the Golfete Dulce. The Chocón Machacas and Golfete Dulce complex forms one of Guatemala's few remaining habitats for the endangered Caribbean manatee (Trichechus manatus).

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