Wales House may refer to:
Australia
Wales House, Sydney, a heritage-listed former office building, bank building and now hotel in Sydney, New South Wales
Belgium
Wales House (Brussels), the Welsh Government office in Belgium
United States
Mary Anne Wales House, Dublin, New Hampshire, listed on the National Register of Historic Places (NRHP) Wales House (Hyde Park, New York), NRHP-listed Wales (Petersburg, Virginia), a historic house and plantation, NRHP-listed North Wales (Warrenton, Virginia), a historic house and plantation, NRHP-listed