Runkle is a surname. Notable people with the surname include:
Benjamin Piatt Runkle, (1836–1916), founder of Sigma Chi fraternity, colonel in the Union Army during the American Civil War Bertha Runkle (1879–1958), American novelist and playwright; daughter of Lucia John Daniel Runkle (1822–1902), US educator and mathematician Lucia Runkle (1844–1922), American editorial writer; mother to Bertha Nathan Runkle (born 1984), American animal rights advocate Theadora Van Runkle (1929–2011), American costume designer
See also Runkle, West Virginia, unincorporated community