Clarke County may refer to:

Places One of five counties in the United States: Clarke County, Alabama Clarke County, Georgia Clarke County, Iowa Clarke County, Mississippi Clarke County, Virginia Clarke County, New South Wales, in Australia

Clarke County was also the official name of Clark County, Washington from 1849 until 1925, when the spelling was changed.

Ships , a United States Navy tank landing ship in commission as USS LST-601 from 1944 to 1955 and as USS Clarke County in 1955 and during the late 1960s

See also Clark County (disambiguation)