Mark Greene, M.D. is a fictional character from the American medical drama series ER. Portrayed by actor Anthony Edwards, he first appeared in the series' pilot episode, as well as subsequently appearing as one of the principal characters until the end of the eighth season. Edwards later returned to make a guest appearance in the fifteenth season episode "Heal Thyself".

Considered to be the lead protagonist of the series’ first eight seasons, Greene's role was that of a mediator and occasional authority figure. He begins the series as the ER's chief resident, before being promoted to an attending physician. He became the only member of the original set of main characters who died during the series.

Character background Mark Greene, an only child, was raised by his mother, Ruth (portrayed by Bonnie Bartlett), and father, David (portrayed by John Cullum). David Greene served in the United States Navy, and thus the family moved frequently and lived all over the country, including Jacksonville, Florida, Norfolk, Virginia, Corpus Christi, Texas, Washington D.C., Kings Bay, Georgia, and Hawaii, where they spent three years, David's longest assignment. Greene had a difficult relationship with his father; as a youth he rebelled to upset his father and he set goals different from what he believed his father wanted. He felt his father favored his Navy career over his family, only to learn in adulthood that David turned down a promotional track to admiral to come home and help Greene deal with a bully. The family's time spent in Hawaii was the most memorable for Greene and he attempted to recreate this with his daughter Rachel during the last few weeks of his life.

During high school Greene developed a romantic relationship with Jennifer, who would go on to become his first wife. Their daughter, Rachel, was born shortly after they married. During medical school he met and befriended future colleague Doug Ross. Greene completed his internship and residency in the Emergency Department of County General Hospital in Chicago, Illinois, and then became Chief Resident of the Emergency Department. Greene developed close friendships with Susan Lewis and Carol Hathaway, and continued his friendship with Ross. Greene's marriage to Jennifer is strained by his workload and by her decision to complete law school, which monopolizes much of her time.

History In the pilot episode, which takes place on St. Patrick's Day 1994, Greene, the chief resident, is awakened in the first scene to help Ross, the emergency pediatric fellow who often comes in on his nights off to sober up after carousing. His close friendship with Lewis is also shown as they confide in each other about their personal lives while on break. During the same episode, Jennifer convinces Greene to visit a private practice near the hospital in hopes he will change careers for more family-friendly hours. Greene decides against this career change. During his night shift at the ER, Greene urges the staff to return to work after Hathaway is rushed in due to a suicide attempt.

During the first season, Greene's marriage is increasingly strained. When offered an attending physician's position by David Morgenstern, Greene accepts. Jennifer has been clerking for a judge in Milwaukee and becomes increasingly tired of commuting and living separately to accommodate Greene's career. She begins an affair with a coworker, and the marriage soon ends, with Rachel and Jennifer leaving Chicago first for Milwaukee and later for St. Louis.

In "Love's Labor Lost", Greene miscalculates treatment of a pregnant woman that leads to her death in childbirth; the aftereffects of Greene's judgment continue into the second season.

In "A Miracle Happens Here", a Christmas episode, Greene explains that he is the son of an agnostic Jew and a lapsed Catholic. He lights a Hanukkah candle for a Holocaust survivor.Season 2, Episode 10. Greene understands some Yiddish.The expression Loch in kop.

Greene's administrative position requires him to make decisions that periodically alienate his friends, such as selecting Kerry Weaver for Chief Resident over another applicant, angering Lewis as the other applicant is friends with Lewis and Weaver is widely disliked. Greene's friendship with Ross becomes strained as Greene's administrative responsibilities put him at odds with Ross.

His romantic feelings for Lewis grow but she leaves the hospital for a job in Phoenix, Arizona. He suffers psychologically after he is attacked and severely beaten in a hospital restroom in the episode "Random Acts". The attack is initially believed to have been carried out by Christopher Law, the brother of a patient who died after Greene treated him for a gunshot wound. Law claims Greene failed to save his brother's life because of his race, as Greene had incorrectly assumed Law and his brother were gangbangers. Later, the show implies the assailant was a psychotic individual who was randomly attacking doctors; Greene's attacker is never caught. After the attack Greene buys a gun and, in an uncharacteristic moment, threatens a group of teenagers with it who were harassing and following him on a train platform; soon after, Greene throws the gun into the river. Greene struggles through a large part of season 4 but comes to terms with his attack in season 5 when he helps Nigerian-born janitor Mobilage Ekabo reveal Ekabo's memories of torture by talking about Greene's own attack with Ekabo, allowing Ekabo to obtain political asylum and avoid deportation.

Greene and Ross travel to California to settle Ross' father's affairs after he died in a car accident; they also visit Greene's parents. Greene's mother is suffering from medical conditions associated with her age and Greene's relationship with his father, David, is awkward. Greene also learns that his mother, Ruth, married David without knowing him well after learning she was pregnant. Greene's distrust of the Navy puts him at odds with David when the two argue over whether Ruth should be treated in a naval hospital or a civilian hospital. Ruth eventually dies and Mark attends to her funeral. Greene then clashes with Kerry Weaver after Weaver supports Robert Romano's bid to become chief of the ER, when the two had already agreed to oppose it.

Greene's personal life after his marriage ends is tumultuous. He engages in several flings, including with nurse Chuny Marquez. In one instance, Greene sets up three dates in one day, which results in disaster when the three women all find out. He has a brief relationship with desk clerk Cynthia Hooper (played by Mariska Hargitay) in season 4. Hooper tries to rush the relationship, causing Green to pull back. But later, fearing being alone, he tries to reconcile with her, but she refuses when she accepts he does not love her.

Greene eventually meets visiting British surgery fellow Elizabeth Corday. Greene and Corday begin a healthy, stable relationship in season 5.

During season 6, Mark's mother passes away unexpedtedly and months later, Greene learns that David is suffering from advanced lung cancer. After David realises he can no longer live alone, he moves to Chicago to live with Greene. Father and son reach an emotional bonding that heals the difficult relationship from Mark's youth, and David eventually succumbs to his cancer.

Greene and Corday move in together, become engaged and get pregnant. But their happiness is short-lived when Mark discovers he has a brain tumour. Initially diagnosed as inoperable, the two travel to New York, where they are given hope when a specialist surgeon agrees to operate.

Mark's surgery is a success, and he and Elizabeth marry and have a daughter, Ella. Their happiness is threatened when the abusive father of a patient goes on a murderous rampage after social services take his son at Greene's prompting. The father kills and injures a number of people but is stopped before he can attack Corday and Ella. After being shot by an armed bystander, the father is brought to the ER. During the father's treatment, Greene takes him aboard an elevator on the way to an operating room. The father goes into cardiac arrest and Greene withholds defibrillation, allowing him to go into ventricular fibrillation and die. Greene falsifies records to show that he attempted to save the patient.

Later, Greene's daughter Rachel appears in Chicago unannounced, citing arguments with her mother, and moves in with Greene and Corday. Ella overdoses on drugs she finds in Rachel's backpack in season 8, putting a strain on the marriage and Greene's relationship with Rachel.

Character illness and death While suturing a patient's wound, Greene loses control of his faculties and is temporarily unable to speak. After a CT scan and a biopsy, he is diagnosed with an aggressive form of brain cancer, glioblastoma multiforme, that is thought to be inoperable. Embarrassed, Greene briefly tries to hide his condition, but his cover is blown when he has a seizure while arguing with Carter.

With little time, Greene seeks a second opinion from an eminent New York City neurosurgeon, Dr. Burke. Greene is told that the tumor is near a critical section of his brain but has not "invaded" it yet and they can perform an operation on New Year's Eve 2000. Greene's surgery is performed by Burke and things appear to be positive, although it takes him a while to return to his old self. A year or so later, however, Greene finds out his tumor has returned, and Dr. Burke both confirms this and says he cannot operate again because the tumor regrowth is now in part of his brain where an operation would render Greene completely vegetative.

At this point, Rachel has run away from Jen in St. Louis and is staying with Mark and Elizabeth. Though she vehemently denies it, her recreational drug use becomes apparent when her sister Ella gets hold of some ecstasy in her backpack and nearly dies after ingesting it in the episode "Damage is Done".

When Rachel shows up, Mark can barely control his anger at her, berating her for repeatedly lying to him and for putting Ella in danger. However, he sees her remorse and fear for Ella are genuine. Knowing that Elizabeth is angry enough for both of them, he hugs Rachel when she starts to cry. When Mark refuses to throw Rachel out of the house, Elizabeth says she will not return home with Ella as long as Rachel is there and leaves home with Ella and moves into a hotel. Unwilling to tell Elizabeth about his condition, Mark stays with Susan (who at this point had returned to County General) during the course of his chemotherapy and radiation treatments. Elizabeth later finds out the truth and wants to come home, but Mark tells her she should not pretend to be his wife just because he is sick. However, she returns anyway and begins helping Mark as his illness advances. Mark suffers additional medical problems and his time in the ER comes to an end. Eventually, however, he resigns himself to his fate and decides to halt the debilitating chemotherapy, deciding he would rather have three good final months than twice that suffering from his treatments.

On his last day in the ER, he meets the same older woman that viewers saw on the first episode of ER. She again has a hangnail and complains about how painful it is. Greene tells her that he has an inoperable tumor, asks another doctor to treat her, and tells the patient not to return to the ER again. He leaves the ER, stops his chemotherapy treatments, tells John Carter that he will now "set the tone" and takes Rachel on a last-minute trip to Hawaii to rebuild his relationship with her and relive happier times.