Caffi is an Italian surname. Notable people with the surname include:
Alex Caffi (born 1964), Italian Formula One driver Alex Caffi (ice hockey) (born 1990), Italian ice hockey goaltender Francesco Caffi (1778–1874), Italian councillor and musicologist Ippolito Caffi (1809–1866), Italian architectural painter Margherita Caffi (1648–1710), Italian still life painter María Teresa Infante Caffi (born 1950), Chilean judge Pedro Pablo García Caffi (1944–2022), Argentine singer and cultural administrator Urbain Caffi (1917–1991), Italian-born French racing cyclist
See also Museo di Scienze Naturali Enrico Caffi, natural history museum in Bergamo