Apthorp is a surname and may refer to:
Benjamin Apthorp Gould (1824–1896), American astronomer Benjamin Apthorp Gould Fuller (1879–1956), American philosopher Charles Apthorp (1698–1758), American merchant and slave trader Frederick Apthorp Paley (1815–1888), English classical scholar John Apthorp (1935–2024), British businessman specializing in frozen food and alcoholic beverages John T. Apthorp (1769–1849), American banker Sarah Wentworth Apthorp Morton (1759–1846), American poet William Foster Apthorp (1848–1913), American music professor and critic William Lee Apthorp (1837–1879), American surveyor, military leader
See also The Apthorp, apartment building in New York City Apthorp Farm, a one-time farm on the Upper West Side of Manhattan Apthorp's Island, Massachusetts Apethorpe, village in England