ACSL may refer to:
American Computer Science League, a computer science competition primarily among US high school students Advanced Continuous Simulation Language, a computer language ANSI/ISO C Specification Language, a formal specification language for C programs Association of School and College Leaders, a British professional association Human genes encoding Acyl-CoA synthetase long-chain enzymes: ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 SLC27A2 The Anti-Capitalist Software License