Killion is an uncommon surname of Irish and German origin.

Notable people Ann Killion (birth date unknown), American sports journalist and writer David T. Killion (born 1966), American government official and diplomat John J. Killion (1859-1937), American boxer better known as "Jake Kilrain" Kyle Killion (born 1984), American football linebacker Redley A. Killion (born 1951), Micronesian politician Ruth Ann Killion (1949–2021), American government statistician Sarah Killion (born 1992), American professional soccer player Sean Killion (born 1967), American swimmer Theophilius "Theo" Killion (birth date unknown), American businessman Thomas H. Killion (born 1957), American politician Tom Killion (born 1953), American fine art printmaker and author

See also Ó Cillín, Celtic family name from which Killion derives Killian, an alternate spelling