SMAC may refer to:
Biology and medicine Second mitochondria-derived activator of caspases or Diablo homolog, a component of the apoptosis pathway Sequential Multiple Analysis - Computer or comprehensive metabolic panel, a panel of clinical chemistry lab tests Supramolecular activation cluster, the structure comprising the immunological synapse
Other uses Sabang Merauke Raya Air Charter, an Indonesian airline Sarah McCreanor, known professionally as Smac Sid Meier's Alpha Centauri, a computer game Social Mobile Analytics Cloud, also called the third platform Southern Maryland Athletic Conference Southwestern Michigan Athletic Conference Stone Mountain Arts Center, an arts center in Brownville, Maine, United States, North America Supreme Macedonian-Adrianople Committee
See also FBi SMAC Awards, Awards given by Sydney radio station FBi Smack (disambiguation)