The Jaci Paraná River () is a river of Rondônia state in western Brazil. It is a tributary of the Madeira River, which it joins at Jaci Paraná in the municipality of Porto Velho, Rondônia
Tributaries of the Jaci Paraná river basin rise in the Guajará-Mirim State Park, created in 1990. The river forms the western boundary of the Jaci Paraná Extractive Reserve, created in 1996.
See also List of rivers of Rondônia
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